© 2016 JUSTIN SU. ALL RIGHTS RESERVED.

Sharing My First Research Conference Experience with The Highlanders

UC Riverside and I go way back. Ten years ago, I was an elementary school boy attending a cousin’s PhD graduation commencement at UC Riverside. Now, for the first time in ten years, I come back to UC Riverside to experience in what many researchers do yearly – presenting at a research conference.

SCCUR – Southern California Conferences for Undergraduate Research. It was their Fall Symposium, and I was eager to share the research I have done this summer. As I arrived, I was not anticipating any food to be catered until lunch, yet a simple breakfast was served. This and especially chugging down a cup of OJ were things I needed to kickstart the day.

After checking in, I sat in an auditorium filled with unfamiliar faces. Introducing myself to who I thought were strangers around me slowly became what was like conversations with my lab mates. We conversed about our research, scientific backgrounds, and undergraduate life. The hall gradually declined in volume as a SCCUR Board Member Dr. Jack Eichler welcomed us and officially commenced the conference. Dr. Susan Wessler, the plenary speaker, soon came up and gave a talk about her research on transposable elements. I was intrigued by learning that a big chunk of our genome consists mostly of these transposable elements that have no apparent use, yet research is finding out that they actually do. Her lab tries to decipher the uses of transposable elements, using some similar techniques which I surprisingly know of. That talk had definitely struck an accord with me, © 2016 JUSTIN SU. ALL RIGHTS RESERVED.instilling a drive within me to find out more about transposable elements and connect the dots to what I already know.

After listening to presenters give their talks and eating lunch with our two fellow Gorman Scholars, it was showtime. The poster was up; I was hydrated; and people started shuffling into the room. Having a spot near the entrance to the room definitely got many to take interest in my poster. I was enthused to share with everyone interested in my poster, especially those who knew a lot about microtubules. Whenever there was downtime, I would take the opportunity to learn what my neighbors’ projects were and what they researched. Overall, I was mainly busy throughout the entire session – introducing myself, running down key points throughout my project, and even networking with those around me. The environment itself was lively, yet so nostalgic considering this was my first research conference experience.

Reinforcing my point in my first blog post, you do get the recognition, the food, the drinks, and especially the connections. Driving away from UC Riverside was a bittersweet moment, where I felt happy that it happened and sad that it was over. I learned a lot from SCCUR, and I encourage any undergraduate researcher to experience presenting at a research symposium. In addition, this year’s research experience has been extremely educational, and it sure was a summer well spent. I truly thank CSEP for supporting me and my project this year, and I cannot wait to present at the next research conference that will have me.

© 2016 JUSTIN SU. ALL RIGHTS RESERVED.

A Home Away from Home

When a power outage occurs in Isla Vista and the library closes at 2 AM, there is only one option left for me – the lab. That actually happened. I did not sleep there, of course, though I desperately needed power, warmth, and speakers that can blast me awake. Interestingly enough, I was not alone. One of the graduate students working in my lab was also there. It simply felt like home, where that oh dark hundred became one of the most productive I have been in all summer.

© 2016 JUSTIN SU. ALL RIGHTS RESERVED.

This world also contains a direct view to the ocean and the freshman dorms!

Working in Dr. Zach Ma’s lab opened a new world for me, one that I would not have expected to be in a year ago. A world that contains one of the purest, sterile water on campus, countless bags of pipette tips, and some laboratory equipment that cost more than most luxury cars. Though a chemistry major, I have always found the field of biology intriguing, and joining a cell biology lab before even taking general biology is quite a challenge and a reward. Learning biochemical techniques and operating laboratory equipment these past months were all fascinating fun, yet the reiterated realization of the difference between doing and thinking was a defining moment of this summer. Acknowledging the fact of doing from memorizing was extremely difficult until problems began to arise sporadically. Every experiment has their own situations. Doing based on understanding the scientific concepts and their rationales adapts to those situations, and would have optimized the ideal circumstances for each experiment I ran. Boy, would that help me in organic chemistry.

© 2016 JUSTIN SU. ALL RIGHTS RESERVED.

A year ago, I did not know that it was possible for a freshman to get involved in research, especially cutting-edge research. Though in research, one thing to hone in on is resiliency. No matter if your hypothesis was horrendously wrong, you go back to the drawing board and patiently and logically crank it out. As a part of a research group, I have a family that is willing to come to my aid and motivate me. I can even go to other families around campus and find ways to collaborate, whether they be ideas or equipment. Simply put, we are a family, and this is my home, where I will be making life-defining memories (and scientific discoveries, hopefully) for the years to come.

The Layers of Medicine: My Summer at Stanford

“Can I get a 5:0 Monocryl and 6:0 Fast Absorbing Gut?” I thought after hearing Dr. Aasi repeat the remark over fifteen times a day through the span of my internship I would get tired of the phrase, but the request was precedent to surgery and watching Dr. Aasi perform surgery was number one on my list of preferred summer pastimes. During the short amount of time I was able to spend at Stanford Medicine shadowing Mohs practitioner and surgical oncologist Dr. Sumaira Aasi, I learned more about the nature of doctors and their teams than I did about the details of medicine. Of course I was intrigued by the effectiveness of Moh’s medicine in removing basal cell carcinomas and the many reasons skin grafts can die after being sutured to an open wound and the exact temperature of liquid nitrogen–all fascinating topics of conversation–but the paramount take away from my summer at Stanford was being able to observe the intricate workings of a hospital clinic.

Dr. Aasi and her team resemble a house of cards. It seems as if they can read each other’s minds, always knowing the whereabouts of every patient’s wandering family members and the next tool Dr. Aasi needs placed in her hand. The team flows, with every factor of the equation solved for. One nurse enters a room as soon as the first exits, the rooms are prepped just in time for the doctor to enter, and the slides are presented at perfect moments between surgeries. There is an unspoken understanding of the way things need to go. My first few days of the observership I was following Dr. Aasi around like a lost puppy, equally befuddled and awed at the clockwork that was their clinic.

The Outside: What Field of Medicine?

Dr. Aasi performs surgeries regarding lesions on the skin that can take the form of basal or superficial squamous cell carcinomas, cysts, lipomas, or keloids. Basal and squamous cell carcinomas are skin cancers that are contained in the outermost layer of the skin, the epidermis. The cells on the topmost layer of skin are called squamous cells, which are constantly shedding and being replaced by basal cells, located in a lower layer of the epidermis. Basal and sqaumous cell cancers are most commonly developed from sun exposure and poor sun protection. They are found in areas such as the face, back of the neck, arms, ears, or hands. The most  common type of skin cancer is a basal cell carcinoma, a slow growing cancer that is minimally invasive and rarely spreads throughout the body. A squamous cell carcinoma is less likely but has a higher likelihood of spreading to other parts of the body because it is found in deeper layers of the skin.

The two main surgical procedures to treat these carcinomas are Mohs surgery and excisions. The Mohs procedure is practiced when there is a skin cancer present on visible areas of the face. Mohs is beneficial because it preserves as much healthy skin as possible and keeps scarring to a minimum. This treatment involves subsequently removing layers of skin that contain malignant cancer cells and immediately sending them to the lab for analysis of leftover tumor. If cancer cells are identified under the microscope, the doctor goes back in to remove another layer of the skin, and the process is repeated until there are no leftover cancer cells. Similar to removing a rotten chunk of an apple, the removed portion is tested for residual impurities. The process is repeated until the patient’s slides are all cleared, Dr. Aasi averaging between one to three stages per patient.

An excision surgery is performed when the skin cancer is located in more conservative areas of the body such as the back, chest, or abdomen. The procedure removes a larger portion of the skin and cuts deeper than Mohs procedure. The doctor incises around a predictable margin for the tumor and immediately sutures the incision without waiting for lab results. Then, the sample is sent to the lab and the team notifies the patient of the results in a few days.

The Middle: What I Learned from Watching Surgery

The first surgery I watched was a Mohs procedure on the outer cartilage of the ear. After the nurses numb the area by administering shots of lidocaine with epinephrine, Dr. Aasi enters and incises around the tumored area. She gently holds and lifts the thin layer of skin using a pair of tweezers. Next she makes systematic cuts under the lifted layer of skin and runs them smoothly up the incised area until the entire sample is cut loose. Dr. Aasi also makes two grid-like cuts along adjacent sides of the incision to orient the sample in relation to the patient’s body. These grid marks help her understand what she is seeing under the microscope. The practice seems routine, almost too easy for Dr. Aasi’s experienced hands. Her steady, composed form makes the evidently complex operation seem simple.

The nurses take care of most residual duties such cautery and pressure dressings between stages, while Dr. Aasi is usually out the door and already halfway to the lab before I can even turn toward the exit. After each stage, the clinic sends the sample of skin to pathology where Dr. Aasi sketches the shape of the sample and applies a different color dye to each edge. These preliminary duties help her visualize a general map of the sample under the microscope. By adding the blue, black, and red dyes, Dr. Aasi distinguishes top from bottom and left from right in relation to the sketch, which is always drawn in regard to the patient’s left shoulder. The pathologists flatten and cut the sample of skin into several slides that are put through an automatic dye machine and then arranged for the doctor to read.

The first time I observed Dr. Aasi viewing specimens under the microscope I was baffled at the speed at which she zipped through the slides and made calls to clear the patient. While all the cells looked like identical blobs to me, she was able to differentiate between  the misshapen island cells of a tumor and the sweat glands, hair follicles, nerves, and normal skin cells the body produces. Over time Dr.Aasi taught me how to distinguish the cluttered, island like appearance of cancer cells from the rest of the body’s creations. Usually colored darker than the surrounding areas, they show up in clusters, resembling nests of irregularly shaped cells. If any tumor is seen under the slide, Dr. Aasi determines which area of the original sample the tumor is in based on the grid marks and dye she placed on the specimen. Characteristic of Mohs, in subsequent stages Dr. Aasi removes skin only from areas where tumor is still present, preserving as much healthy skin as possible.

The Inside: The Lessons That Changed How I View Medicine

While Dr. Aasi operates on patients she often strikes up conversations about random yet intriguing topics. We find ourselves talking about how classy the Obama family is one minute and the next Dr. Aasi will be reminiscing her college days and how she actually had to go to the library and read a book to do research. These spur of the moment exchanges characterize my most valuable glimpses into Dr. Aasi’s life. She discloses stories about her career in medicine, ranging from her experiences as an attending, the hardships of adjusting to new hospitals, and some of the scariest moments she’s had in an operating room. These stories inspire through character, they mean something because they make the hospital come to life, and it’s stories like this I hope I’m able to tell someday.

Through my time at Stanford I learned so much more than I thought I would. Not just about the nature of dermatologic surgery, which proves to be a job for a doctor, artist, and perfectionist all in one, but also about the unforeseeable speed at which life moves and the pure joy that comes from being able to help people. From hearing the stories of hundreds of patients and watching the doctor cure their illnesses, I got a firsthand glance into the miracles of medicine. After witnessing the pain and suffering associated with cancer, I was moved by the resilience of patients faced with circumstances beyond their control. I was stirred by the selflessness of doctors and the amazed by the rhythm of hospital clinics. I learned more from this experience than could ever be written in a textbook, urging me to learn by facing a constant rollercoaster of emotions. But most importantly I learned to never forget sunscreen.

 

© 2016 JUSTIN SU. ALL RIGHTS RESERVED.

Summer Research Declassified

EUREKA!.2016.S01E01.Summer.Research.Declassified.1080p.BluRay.DD5.1.H264-UCSB

↳ Subtitles.txt


COLD OPEN

FADE IN:

Bill Nye: “EUREKAAAAAAAAAAAAAAA!”

Beck Bennett: Gets an adrenaline rush. Parties hard until rush dissipates. Drafts. Publishes. Spams published paper. Gets invitations. Accepts invitations. Presents in conferences. Gets nominated. Wins nomination. Becomes a Nobel laureate. Finally, SLEEP.

*transition swish*

Morgan Freeman: Clinching a Nobel Prize is one of the lengthiest and arduous attempts. This may take many a lifetime, or a cleverly few, coming in clutch, with one expedited shot at the prize. Space, time, and life itself. The secrets of the cosmos lie through the wormhole.

Neil deGrasse Tyson: Though the timeline to be the most prestigious in the science realm is enticing, saying “EUREKA!” is by no means easy. It all must start with research, and research requires resiliency, critical thinking, perseverance, concentration, self-motivation, and a great deal of time. That is why summer is the best time to get started, where Justin is on the hunt to declassify summer research in this episode of EUREKA!

END OF COLD OPEN

ACT ONE

Justin: Summer is the opportune time to grow as an undergraduate researcher. Not only does one experience the breadth of undergraduate research that UCSB offers, but one can also take the opportunities to communicate one’s research to the public.

As an EUREKA! scholar, I, Justin Su, have been tasked to declassify summer research here at UC Santa Barbara. Conducting research, though crucial for scientific discoveries, is meaningless when the research itself is neither shared nor critiqued by the scientific community. While I am currently working in a cell biology lab to develop my biochemical techniques, EUREKA! is equipping me with the necessary presentation skills for my future conference talks.

Presenting in front of an audience is of the arts that one must master to become a highly acclaimed scientist. It is undoubtedly frightening, especially when the faces of your audience remain expressionless as you begin. Even if you envision the ideal flow of your presentation, the detrimental “noises” in your presentation environment may majorly allocate the audience’s attention bandwidth. I and many presenters must therefore combat these “noises,” especially the personally induced ones. Continuous practice is a harsh, yet imperative, prerequisite to control these noises. Simplification and visualization of information is also essential in retaining the audience’s attention. Additionally, verbal intonation, vocal stability, and bodily expressions will assist in honing the presentation to its ideal and natural form. In the end, you get the fame, the food, the drinks, and the connections, basically all for brief moments on a stage.

Behind the scenes, conducting a personal research project is of the sciences that surprisingly encompasses the execution of many personal values and virtues. In my case, the field of cell biology is extremely logically structured that requires rigorous critical thinking sessions. The virtues of patience, resilience, and open-mindedness are vital when pondering the rationales behind specific mechanisms and pathways. Experimentally, the amount of attention to detail can make or break your experiments, setting off a good or bad domino effect. Whenever it comes to doing Western Blot, immunofluorescent staining, and even mammalian cell culture, I concentrate on being accurate and precise among all my actions to ensure quality and effective data. Despite the time reserved for the experiments, your mind would be like Einstein’s, and it is so worth it (i.e. learning upper-division biology concepts as a freshman). Gradually, however, one will begin to appreciate the science behind these biochemical techniques and analytical skills. By applying your mind, skills, and values to the cutting edge research done here at UCSB, you will be on your way to saying “EUREKA!” in no time.

With the fusion of art and science behind research, the ample space, time, and life that summer at UCSB provides is the epitome for undergraduate researchers to fulfill their potential in becoming groundbreaking, world-renowned scientists in their fields. With a laid-back, sunny Isla Vista during the summer, I could go on runs, film and edit videos, play beach volleyball, chill with my friends, and not worry about weekly exams. Although I am halfway through my first summer research experience, there is so much that I cannot wait to do in my next three years. Until next time, this is EUREKA!’s Summer Research Declassified.

FADE OUT:

END ACT ONE

TL;DR: Be cool like us and do summer research – It’s really lit, fam!

Biology is as Real as the Life it Studies

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STEM majors come in a large assortment — from mathematicians, to physicists, to engineers, to biologists, to doctors. The amount of subdivisions under the STEM umbrella is almost impossible to quantify (but, considering we are STEM majors, of course it’s possible.)

Despite the fact that each field is equally honorable and important in their own right, there remains a hierarchical structure among those pursuing STEM. And which majors are automatically deemed to fall under the lowest possible caste system of science and engineering? The life science majors. The psychology majors. The less quantitative, “soft” science majors.

And why is this the case? Simple. Embedded into our minds is the age old belief that biology, or anything pertaining to the study of life, is qualitative and relies solely on memorization. Between my engineering major friends, there is a joke that goes along the lines of, “Engineering was too difficult for him, so he became a doctor instead.”

While I admire all those who are competent enough to pursue mathematically-intensive professions, let us not bash the ones who helped your mother deliver you as a baby, nor the ones who assessed your head for concussions after a sports-related injury, nor the ones who witness too many deaths and disease-ridden patients for the sake of trying to save people.

I’ve heard counterarguments that engineers can save more lives than doctors merely because they know how to mass produce products — that, depending on what type of product we are referring to, pharmaceutical scientists and biotechnologists help prepare — to the populace, whereas doctors can save only the lives of their patients. But when it comes to life, even just one life is tremendously valuable and deserves to be saved. Don’t you value your life or a loved one’s life perhaps more than the entire population of a country full of strangers? Quality over quantity, ladies and gentlemen. Although preferably, quality and quantity.

Diverging from the clinical side of biology and returning back to the more research-oriented division within biology, the life sciences have, in fact, become more quantitative in this era given how rapidly technology has progressed, and my experiences in a neuroscience lab this summer have only come to reiterate that fact. There are many interdisciplinary aspects to biology now, especially in regards to computer science. The R programming language is useful for ecologists analyzing statistics for a sample and relating their findings to a larger population. In my lab, Python is a wonderful tool for genomics when trying to sort through the millions of base pairs within a single DNA sequence. Electrical engineers may find interesting that biologists do take advantage of multielectrode arrays to map out electrical networks among brain cells. Mechanical and computer engineers can collaborate with biologists to develop artificial organs. Chemical engineers could work alongside biochemists in distributing new pharmaceuticals to target cancer. There doesn’t have to be a dichotomy between math-intensive majors and life science majors. We are all a part of the STEM family, and we function better together than apart.

As a future neuroscientist, I do have to clarify on psychologists. Admittedly, neuroscientists are held in higher esteem because they implement more math than do psychologists. There has also been an irrational rivalry between neuroscientists and psychologists, as neuroscientists focus on the molecular basis of the brain, while psychologists are more interested in the overall function of the brain’s regions. Regardless, they are both interested about the brain. Each play a significant role in understanding the brain, so why are we acting like the Montagues and Capulets? Why despise an enemy who should otherwise be a good friend?

Lastly, to beat down some egotistical arguments (which, if you are a proponent of, you may want to check for hyperactivity in your amygdala, the brain region responsible for emotion): yes, engineers and physicists make more than biologists in this society. We’re aware. No need to rub it in. That’s like if a man were to tell a woman that he’s making $1.00 for every $0.77 she makes, even after the implementation of the Lily Ledbetter Fair Pay Act. Or if a privileged, upper class citizen told a coworker with the same job position that she is making more money because her coworker happens to be in a racial minority group. Football players and actors make more money than combat veterans. Politicians make more money than engineers even after they’ve completed serving their term.

There are many wage disparities that still confound us; however, your salary shouldn’t be how you base your success. Impact. Influence. Happiness. Are you happy doing your job? Are you making enough to support the life you want? How has your work impacted you? Your company? Your country? The world? Will what you are doing influence society, or are all of your efforts just disappearing into the ether?

Engineers are great. Mathematicians are great. Physicists are great. Chemists are great. Geologists are great. Doctors are great. Biologists are great. All STEM professionals are great. All non-STEM professionals are great. We all need one another to function as a healthy society. All I ask, as a life science major, is to not be denigrated or have false assumptions made about my intelligence by the major I chose to pursue.

My research experience in a neurobiology lab this summer and my previous experience in a parasitology lab have made me appreciate biology all the more. We are all trained in our areas of expertise, and I wouldn’t expect a non-biology major to appreciate or want to learn how to reverse transcript RNA into complementary DNA, or manipulate stem cells to differentiate into a brain cancer. That’s okay. What is not okay is belittling the work I do.

Biology is a real science too. And it’s as real as the life it studies.